Award
NIH Reporter #5R01AI137276-09
Mechanisms of Antibody-Dependent Enhancement of Dengue Disease
Recipient
Rockefeller University
Award Amount
$459,711.00
Ceiling
$459,711.00
Awarded
August 20, 2026
Identifier
5R01AI137276-09
NIH funded research project investigating how antibody glycoforms contribute to severe dengue disease through immune activation mechanisms, aiming to inform therapeutic strategies.
Description
This project aims to define the mechanisms by which specific antibody glycoforms are generated during dengue infection and how they contribute to disease pathogenesis. The study focuses on the role of afucosylated IgG antibodies and their engagement with FcγRIIIa on macrophages, which leads to aberrant immune activation, inflammation, and severe dengue outcomes.