Award
National Heart, Lung, and Blood Institute 5R01HL173544-03
Tissue Perfusion Pressure for Improved Management of Circulatory Shock
Recipient
Massachusetts General Hospital, Boston, MA, United States
Award Amount
$768,543.00
Ceiling
$768,543.00
Awarded
May 18, 2026
Identifier
5R01HL173544-03
The project aims to develop a novel hemodynamic metric called tissue perfusion pressure (TPP) to improve management of circulatory shock by providing individualized blood pressure targets through continuous monitoring and computational tools.
Description
This project develops a new approach to monitoring blood pressure in patients with circulatory shock, using computational techniques to provide an improved description of perfusion pressure. It combines studies from preclinical animal models and clinical patients to validate the approach, aiming to set the foundation for future clinical trials.