Award
National Institute of Allergy and Infectious Diseases 1R01AI195745-01
Impact of a Dual Function Type VI Secretion System (T6SS) Immunity Protein on Airway Microbiota
Recipient
Dartmouth College
Award Amount
$825,054.00
Ceiling
$825,054.00
Awarded
February 13, 2026
Identifier
1R01AI195745-01
The award funds research on the impact of a dual function T6SS immunity protein on airway microbiota, focusing on Pseudomonas aeruginosa biofilm formation and microbial interactions in cystic fibrosis airways to identify new therapeutic targets.
Description
This project studies the role of a dual function Type VI Secretion System (T6SS) immunity protein in regulating Pseudomonas aeruginosa biofilm formation and microbial diversity in the airway microbiota, particularly in the context of cystic fibrosis. The research aims to understand how TsiT protein mediates biofilm formation, confers protection against TseT intoxication, and modulates P. aeruginosa fitness during biofilm growth in a cystic fibrosis respiratory microbiota model.