Award
National Institute of Diabetes and Digestive and Kidney Diseases 5R01DK114103-07
Keeping fat out of muscle - Role of Branched Amino Acids in Insulin Resistance
Recipient
University of Pennsylvania
Award Amount
$735,693.00
Ceiling
$735,693.00
Awarded
August 04, 2025
Identifier
5R01DK114103-07
Research funded by the National Institute of Diabetes and Digestive and Kidney Diseases to investigate the mechanisms by which branched-chain amino acids affect insulin resistance and vascular function, potentially leading to new therapeutic approaches for type 2 diabetes.
Description
This project explores the role of branched-chain amino acids (BCAAs) in insulin resistance and blood pressure regulation. It aims to understand how systemic activation of BCAA catabolism improves insulin resistance, focusing on vascular reactivity and glucose tolerance using genetic murine models, vascular physiology assays, hyperinsulinemic euglycemic clamps, and human studies.