Award
National Institute on Deafness and Other Communication Disorders 1F31DC023096-01
Toward vocal fold scar mitigation through CRISPR/Cas-9-mediated gene editing of fibroblasts
Recipient
Michelle Bretl
Award Amount
$52,538.00
Ceiling
$52,538.00
Awarded
March 19, 2025
Identifier
1F31DC023096-01
Research project funded by the National Institute on Deafness and Other Communication Disorders to mitigate vocal fold scarring through gene editing techniques targeting fibroblasts.
Description
This project aims to identify genetic targets to reduce vocal fold scarring using CRISPR/Cas9 gene editing and RNA sequencing, with a focus on inhibiting TGF-β signaling pathways to prevent myofibroblast differentiation and fibrosis.