Award
National Institute of Allergy and Infectious Diseases 5R01AI127193-10
Structure-function studies of the membrane-interacting domains of HIV-1 Env spike
Recipient
Boston Children's Hospital
Award Amount
$816,248.00
Ceiling
$816,248.00
Awarded
July 17, 2025
Identifier
5R01AI127193-10
NIH funded research project to study the structure and function of membrane-interacting domains of HIV-1 Env spike using NMR and cryo-EM to understand viral entry and immune response mechanisms.
Description
This project aims to determine atomic structures of membrane-interacting domains of HIV-1 Env and related proteins in a physiologically relevant environment. The study will utilize NMR technology and cryo-electron microscopy to investigate the roles of these domains in membrane fusion, stability, function, and antigenicity.