Award
National Institute of Environmental Health Sciences 1R21ES036352-01A1
Developmental pyrethroid exposure in the Shank3 mutant prairie vole as a 2-hit model for neurodevelopmental disorder risk
Recipient
University of Toledo Health Science Campus
Award Amount
$421,047.00
Ceiling
$421,047.00
Awarded
August 14, 2024
Identifier
1R21ES036352-01A1
This award funds research investigating how genetic and environmental factors combine to influence autism risk, using a prairie vole model to study the effects of Shank3 gene mutation and pyrethroid pesticide exposure on neurodevelopmental outcomes.
Description
Study of the interaction between a genetic risk factor (Shank3 haploinsufficiency) and an environmental risk factor (developmental exposure to the pyrethroid pesticide deltamethrin) in the prairie vole to test dose-dependent effects on autism-relevant behaviors and MAPK/mTOR signaling pathways.