Award
National Institute of General Medical Sciences 5R35GM147491-04
Computational models of cell mechanosensing through integrin-based adhesions
Recipient
Utah State Higher Education System--University of Utah
Award Amount
$382,030.00
Ceiling
$382,030.00
Awarded
August 26, 2025
Identifier
5R35GM147491-04
The award funds research to develop computational models to understand integrin protein mechanosensing and its role in cell motion, with potential applications in treating diseases like cardiovascular conditions, fibrosis, and cancer.
Description
This research develops new computational methods based on all-atom simulations to quantify how the molecular structure and function of integrin transmembrane proteins enable the conversion of mechanical signals into cell motion. The study aims to identify targets for treatments of diseases related to mechanotransduction and provide a basis for designing smart materials responsive to mechanical signals.