Award
NIH Reporter #1R21AR084708-01
Mechanisms of Reverse Transendothelial Migration in Arthritis Resolution
Recipient
University of Missouri-Columbia, Columbia, MO, United States
Award Amount
$366,797.00
Ceiling
$366,797.00
Awarded
September 24, 2024
Identifier
1R21AR084708-01
This NIH-funded project investigates the mechanisms by which neutrophils resolve inflammation in Lyme arthritis through reverse transendothelial migration, aiming to uncover therapeutic targets for chronic inflammatory diseases.
Description
The project aims to examine the role of reverse transendothelial migration (rTEM) of neutrophils in the resolution of Lyme arthritis. It focuses on understanding how neutrophils that enter tissues during inflammation either undergo apoptosis or exit via rTEM, and how mediators like LTB4, PGE2, and LXA4 influence this process.