Award
National Institute on Aging 5R01AG080917-05
Modeling functional genomics of susceptibility to the persistent effects of environmental toxins in an elderly rural Indiana neurodegenerative cohort
Recipient
Purdue University
Award Amount
$733,426.00
Ceiling
$733,426.00
Awarded
June 08, 2026
Identifier
5R01AG080917-05
NIH funded research project at Purdue University to study genetic pathways and environmental toxin effects on neurodegenerative diseases in an elderly Indiana cohort using advanced genomics and cell modeling.
Description
This project aims to identify shared genetic pathways that promote persistent neurotoxic states in individuals residing in northern Indiana through in vitro functional genomics. The study will utilize subject-specific human induced pluripotent stem cells (hiPSCs), zebrafish, and C. elegans models to understand gene-environment interactions leading to neurotoxicity. The research addresses the complex gene-environment interactions involved in neurodegenerative diseases such as Alzheimer's and Parkinson's.