Award
National Institute on Aging 5R01AG070866-05
Investigating the Temperature Dependence of Age-related Tau Pathology Relevant to Early Alzheimer's Disease
Recipient
New York University School of Medicine
Award Amount
$780,675.00
Ceiling
$780,675.00
Awarded
April 10, 2025
Identifier
5R01AG070866-05
NIH grant awarded to New York University School of Medicine to study the relationship between body temperature and tau pathology in Alzheimer's disease among older adults, aiming to identify modifiable risk factors.
Description
This research investigates how subtle decreases in body and brain temperature influence tau protein pathology, a key feature of Alzheimer's disease. Using advanced tau PET imaging and telemetric thermometry, the study will analyze a larger sample of older adults to verify the association between body temperature and tau NFT accumulation. The findings could identify modifiable risk factors and inform future interventions to prevent disease progression.