Award
NIH Reporter #5P50AR072000-10
Elucidating the Mechanisms of S. aureus Motility in Bone and Developing Interventions
Recipient
University of Rochester
Award Amount
$308,048.00
Ceiling
$308,048.00
Awarded
July 29, 2026
Identifier
5P50AR072000-10
The award supports research on Staphylococcus aureus infection mechanisms in bone and the development of PBP4 inhibitors to prevent osteomyelitis, addressing challenges in treating musculoskeletal infections and antibiotic resistance.
Description
This project aims to understand how Staphylococcus aureus moves within bone tissue and to develop interventions to prevent and treat osteomyelitis caused by this bacterium. It focuses on the role of penicillin binding protein 4 (PBP4) in bacterial propagation and the development of PBP4 inhibitors as therapeutic candidates.