Award
National Heart, Lung, and Blood Institute 5R01HL165792-04
Understanding the roles of cardiac NAD pools and therapeutic effects of precursor supplements in heart failure
Recipient
University of Pennsylvania, Philadelphia, PA, United States
Award Amount
$634,840.00
Ceiling
$634,840.00
Awarded
August 04, 2025
Identifier
5R01HL165792-04
Research grant to study NAD+ metabolism's role in heart failure and develop therapeutic approaches using precursor supplements.
Description
This project explores the hypothesis that nicotinamide adenine dinucleotide (NAD+) metabolism can be targeted to improve functional capacity in failing human hearts. It involves innovative surgical models, genetics, and mass spectrometry techniques to understand the mechanisms of NAD+ in cardiac physiology and develop therapeutic approaches for heart failure.