Award
National Institute on Aging 4R01AG088690-03
The impact of inherited and modifiable risk factors on clonal hematopoiesis and age-related disease
Recipient
Washington University
Award Amount
$3,158,066.00
Ceiling
$3,158,066.00
Awarded
July 29, 2026
Identifier
4R01AG088690-03
This award funds research to investigate how inherited and lifestyle risk factors affect clonal hematopoiesis and its link to age-related diseases like cardiovascular disease and Alzheimer's disease, using extensive biobank and longitudinal data.
Description
Clonal hematopoiesis (CH) is associated with age-related diseases such as cardiovascular disease (CVD) and Alzheimer's disease (AD). This project aims to understand how inherited and lifestyle risk factors influence CH evolution and its connection to these diseases. The study leverages large-scale biobank data, longitudinal profiling, and cohorts with over 30 years of follow-up, including the UK Biobank, the Health Professionals Follow-up Study, and the Knight Alzheimer's Disease Research Center.