Award
National Institute of Diabetes and Digestive and Kidney Diseases 5K08DK140637-03
Modulatory effects of a retinoid-related protein on intestinal endocrine cells
Recipient
Columbia University Health Sciences
Award Amount
$166,644.00
Ceiling
$166,644.00
Awarded
April 28, 2026
Identifier
5K08DK140637-03
This award funds research on how the retinoid-binding protein RBP2 affects intestinal endocrine cells, with implications for diabetes and metabolic disease treatment.
Description
The project investigates the modulatory effects of retinoid-related proteins, particularly RBP2, on intestinal enteroendocrine cells (EECs), focusing on hormone production and cell homeostasis. It aims to understand how RBP2 influences EEC proliferation, migration, survival, and hormone secretion, using transgenic mouse models and cell/organoid lines.