Award
National Heart, Lung, and Blood Institute 5R01HL181372-02
Chromatin Regulation of Immune Cells in Myocardial Inflammation
Recipient
J. DAVID GLADSTONE INSTITUTES
Award Amount
$765,888.00
Ceiling
$765,888.00
Awarded
July 31, 2026
Identifier
5R01HL181372-02
Research project funded by the National Heart Lung and Blood Institute to study BRD4's role in immune cell regulation during myocardial inflammation, aiming to find therapeutic targets to reduce chronic inflammation and improve heart failure outcomes.
Description
This project focuses on epigenetic regulation of immune cells in myocardial inflammation, aiming to uncover the epigenetic mechanisms that drive maladaptive immune responses after myocardial infarction, focusing on BRD4 and its role in cardiac macrophage function to identify therapeutic targets to reduce chronic inflammation and improve outcomes in heart failure patients.