Award
National Institute of Neurological Disorders and Stroke 5R33NS133955-03
Screening for Nuclear Receptor TLX ligands
Recipient
University of Florida
Award Amount
$452,934.00
Ceiling
$452,934.00
Awarded
May 05, 2026
Identifier
5R33NS133955-03
This award supports the development and validation of assays to identify and optimize synthetic agonists of the nuclear receptor TLX, which may enhance neurogenesis and cognitive function in dementia patients.
Description
The project focuses on developing, refining, and validating assays for high-throughput screening (HTS) to identify TLX ligands, followed by evaluation and optimization of potential therapeutic agents. It aims to develop biochemical assays for HTS to discover TLX agonists, evaluate hits for further optimization, and ultimately identify candidates for future clinical studies targeting neurodegenerative disorders including Alzheimer's disease.