Award
National Heart, Lung, and Blood Institute 5R01HL177025-02
Imaging the Respiratory Effects of Truncal Adiposity in Acute Hypoxemic Respiratory Failure
Recipient
Massachusetts General Hospital, Boston, MA, United States
Award Amount
$655,603.00
Ceiling
$655,603.00
Awarded
August 03, 2026
Identifier
5R01HL177025-02
This NIH-funded project studies the impact of truncal adiposity on lung collapse and severity of acute hypoxemic respiratory failure using CT imaging and bedside diagnostic tools, aiming to improve personalized clinical management for obese patients with AHRF.
Description
Research project to elucidate how truncal adiposity influences lung collapse and severity of acute hypoxemic respiratory failure (AHRF) using CT imaging, and to evaluate bedside tools like esophageal manometry, forced oscillation, and electrical impedance tomography to detect effects of truncal loading. The project involves animal models and human studies to measure associations between thoracic adiposity, intrathoracic pressure, and lung collapse.