Award
National Institute on Aging 1R01AG092298-01A1
Neural Mechanisms underlying the benefits of Aerobic Exercise in Advanced Parkinson's disease
Recipient
Cleveland Clinic Lerner College of Medicine
Award Amount
$665,118.00
Ceiling
$665,118.00
Awarded
September 11, 2025
Identifier
1R01AG092298-01A1
The award funds a research project investigating how aerobic exercise benefits advanced Parkinson's disease patients with deep brain stimulation by studying motor, cognitive, and neural effects over time.
Description
This project will determine the long-term effects of two modes of aerobic exercise, compared to a no-exercise control group, on the motor, cognitive, and dual-task performance in advanced people with Parkinson’s disease (PwPD) with deep brain stimulation. Despite comprising 25-50% of the PD population, no trials have evaluated the effects of exercise on advanced PwPD function. For the first time, this project will determine the global impact of exercise on advanced PwPD while simultaneously recording neural data from the subthalamic nucleus (STN) and cortical regions before, after, and 4 weeks after exercise cessation to understand the mechanism(s) underlying the potential benefits of exercise on PD.