Award
NIH Reporter #5R01AG079913-04
Role of adipose tissue inflammaging and metabolic dysfunction during sepsis
Recipient
University of Minnesota, Minneapolis, MN, United States
Award Amount
$557,051.00
Ceiling
$557,051.00
Awarded
December 19, 2025
Identifier
5R01AG079913-04
Research grant awarded to study the role of adipose tissue inflammation and metabolic dysfunction in sepsis, particularly in elderly populations, by examining immune cell activity and metabolic pathways in mice models.
Description
The project investigates how immune cell activation within visceral adipose tissue contributes to sepsis susceptibility in the elderly, focusing on inflammasome-activated macrophages and adipose B cells that inhibit lipolysis. It aims to define lipolytic response differences in old vs. young mice, the role of inflammasome activation and GDF3 in inflammation, and adenosine signaling's impact on lipolysis during endotoxemia.