Award
National Institute of Neurological Disorders and Stroke 5R01NS111041-05
The effect of muscle-specific anchoring protein on the biology of the Neuromuscular system
Recipient
University of Michigan at Ann Arbor
Award Amount
$426,301.00
Ceiling
$426,301.00
Awarded
March 15, 2024
Identifier
5R01NS111041-05
NIH research grant awarded to University of Michigan to study the role of muscle-specific anchoring protein in neuromuscular junction biology, focusing on synaptic development and receptor stability relevant to neuromuscular diseases.
Description
The project explores the role of muscle calmodulin kinase II-related anchoring protein (αkap) on synaptic development and AChR stability at neuromuscular junctions. It aims to investigate the effects of αkap knockdown and gain of function in healthy and compromised NMJs, and to understand the molecular mechanisms involving the DGC sub-complex and USP9X in receptor stability. The outcomes are relevant for neuromuscular diseases with compromised receptor density.