Award
National Eye Institute 1R56EY036406-01A1
Mitochondrial factories for AMD therapy
Recipient
Methodist Hospital Research Institute
Award Amount
$1,029,472.00
Ceiling
$1,029,472.00
Awarded
April 28, 2026
Identifier
1R56EY036406-01A1
Award for research on using engineered mesenchymal stem cells to treat age-related macular degeneration by targeting mitochondrial dysfunction.
Description
This project involves a cell-based strategy to target mitochondrial dysfunction in age-related macular degeneration (AMD). It proposes using mesenchymal stem cells (MSCs) engineered for mitochondrial biogenesis, with overexpression of nuclear respiratory factor 1 (NRF1), to transfer mitochondria to retinal cells, potentially reversing AMD progression.