# NIH Reporter #1R01GM169397-01

Integrating Language Models and Topology for Multi-Scale R-Loop Prediction

**Recipient:** University of California at Davis

**Award Amount:** $409,731.00
**Ceiling:** $409,731.00

**Awarded:** September 02, 2026

**Identifier:** 1R01GM169397-01

Research to predict where R-loops form and how DNA topology shapes their structure, using laboratory experiments, mathematical modeling, and machine learning.

### Description

The project develops a predictive, multi-scale quantitative framework combining experimental techniques with mathematical and machine-learning models to study R-loop formation, DNA topology, and three-dimensional structure.

[View original record](https://reporter.nih.gov/search/47CiHD0bJ0u2LtDABS0zbg/project-details/11536586)