Award
National Heart, Lung, and Blood Institute 5R01HL169530-03
Mechanism of F-18-fluorodeoxyglucarate accrual in myocardial injury
Recipient
University of Oklahoma Health Sciences Center, Oklahoma City, OK
Award Amount
$362,500.00
Ceiling
$362,500.00
Awarded
April 28, 2026
Identifier
5R01HL169530-03
NIH grant awarded to University of Oklahoma Health Sciences Center to study a novel PET imaging agent for early detection of myocardial fibrosis, potentially improving treatment outcomes for heart disease patients.
Description
This project investigates the mechanistic basis of a new imaging agent, 18F-labeled glucaric acid, for PET imaging of fibrosis associated with acute myocardial injuries. The agent enables high resolution and sensitivity in diagnostic imaging of myocardial fibrogenesis, aiming to improve outcomes of medical therapy or surgical intervention in patients with myocardial diseases.