Award
NIH Reporter #2P01AI148102-06
Arid5b regulation of pathogenic fibroblast states
Recipient
Brigham and Women's Hospital, Boston, MA, United States
Award Amount
$367,355.00
Ceiling
$367,355.00
Awarded
June 01, 2026
Identifier
2P01AI148102-06
This NIH-funded project studies the epigenetic regulation of fibroblast phenotypes in rheumatoid arthritis by ARID5B, aiming to improve understanding and treatment of non-responder patients through genetic and murine model research.
Description
The project focuses on the role of the transcription factor ARID5B in regulating inflammatory and invasive fibroblast programs in rheumatoid arthritis (RA). It aims to elucidate ARID5B's function, identify genetic variants affecting it, and assess its impact in murine models to target fibroblast effector functions in non-responder patient populations.