Award
National Heart, Lung, and Blood Institute 5R01HL167513-04
Targeting ZNF410 for HbF reactivation
Recipient
Boston Children's Hospital, Boston, MA, United States
Award Amount
$658,954.00
Ceiling
$658,954.00
Awarded
April 06, 2026
Identifier
5R01HL167513-04
Research project funded by the National Heart Lung and Blood Institute to explore targeting ZNF410 for reactivating fetal hemoglobin as a treatment for sickle cell disease and beta-thalassemia.
Description
This NIH-funded research project focuses on gene regulation and therapeutic development for sickle cell disease and beta-thalassemia by targeting the gene ZNF410 to induce fetal hemoglobin in adult red blood cells. The project aims to understand ZNF410's role in gene expression, investigate its biological functions, and develop small molecule degraders as potential therapeutics.