Award
National Institute of Allergy and Infectious Diseases 1R01AI189709-01A1
Dynamic metabolic rewiring determines immune outcomes of chronic cardiac transplant outcomes
Recipient
University of Maryland Baltimore
Award Amount
$770,199.00
Ceiling
$770,199.00
Awarded
August 03, 2026
Identifier
1R01AI189709-01A1
Research grant awarded to University of Maryland Baltimore by NIAID to study how microbiome-induced metabolic changes affect immune outcomes in chronic cardiac transplant rejection, aiming to improve graft survival and develop new therapeutic targets.
Description
This project aims to explore the microbiome's role in transplant rejection and develop microbial and metabolic targets for monitoring, diagnostics, and therapeutics in transplantation. It focuses on defining microbiome-induced metabolic reprogramming in cardiac transplantation, determining metabolically driven alloantigen-specific responses, and characterizing responses induced by fecal microbiota transfer from human recipients.