Award
NIH Reporter #5R35GM155058-03
Probing protein structure and aggregation in complex environments with 2D IR spectroscopy
Recipient
Vanderbilt University
Award Amount
$395,943.00
Ceiling
$395,943.00
Awarded
August 31, 2026
Identifier
5R35GM155058-03
This award funds research to develop advanced 2D IR spectroscopic methods to study protein structure and aggregation, with applications to Alzheimer’s disease and nanoparticle-protein interactions.
Description
The proposed research aims to develop new spectroscopic methods to study protein structure and dynamics in complex environments. It focuses on using 2D IR spectroscopy to measure vibrational couplings in proteins, particularly the Alzheimer’s β-amyloid protein, to understand aggregation pathways relevant to Alzheimer’s disease. Additionally, it investigates how nanoparticles affect protein structure, examining effects of metallic and silica NPs on model peptides and lysozyme. Machine learning approaches will enhance spectral sensitivity and resolution.