Award
National Institute on Aging 5K99AG088296-02
Understanding the relationship between cortical hyperexcitability and the progression of FTD/ALS pathology and behavioral deficits in mice
Recipient
Moustafa Algamal
Award Amount
$112,070.00
Ceiling
$112,070.00
Awarded
July 31, 2025
Identifier
5K99AG088296-02
Research project funded by the National Institute on Aging to study cortical hyperexcitability and its role in the progression of FTD/ALS pathology and behavioral deficits in mice, using advanced neuronal monitoring and manipulation techniques.
Description
This project explores the underlying mechanisms of Frontotemporal Dementia (FTD) by employing advanced technology for neuronal activity monitoring and manipulation. The project aims to understand the relationship between cortical hyperexcitability and the progression of FTD/ALS pathology and behavioral deficits in mice. The project involves research in neurodegenerative diseases, with a focus on FTD and ALS, utilizing techniques such as multiphoton microscopy, optogenetics, and electrophysiology.