Award
NIH Reporter #5P01AG026572-20
Perimenopause in Brain Aging and Alzheimer's Disease
Recipient
National Institute on Aging (NIA)
Award Amount
$2,919,843.00
Ceiling
$2,919,843.00
Awarded
August 19, 2025
Identifier
5P01AG026572-20
Research project funded by the National Institute on Aging to study the increased risk of Alzheimer's disease in women during perimenopause, aiming to develop preventive therapeutic strategies using advanced models and biomarker analysis.
Description
The project focuses on understanding why women are at greater risk for Alzheimer’s disease during the perimenopausal transition and aims to develop therapeutic strategies for prevention and delay. The project involves multiple research projects and cores, utilizing humanized APOE mouse models, brain imaging, and biomarker analysis. It emphasizes mechanistic, clinical, and population discovery science, with a focus on neuro-immune biomarkers and precision medicine approaches.