Award
National Heart, Lung, and Blood Institute 5R01HL175312-02
Epigenomic mechanisms of cardiac fibrosis and heart failure
Recipient
J. DAVID GLADSTONE INSTITUTES
Award Amount
$773,842.00
Ceiling
$773,842.00
Awarded
July 31, 2026
Identifier
5R01HL175312-02
Research project funded by NIH to study epigenomic mechanisms in cardiac fibrosis and heart failure, focusing on the role of MEOX1 in fibroblast activation and disease pathogenesis.
Description
The project focuses on the epigenomic mechanisms of cardiac fibrosis and heart failure. It involves genetic mouse models, cell lines, and advanced transcriptional, epigenomic, and computational approaches. The goal is to determine if MEOX1 functions as a key transcriptional regulator in fibroblast activation, fibrosis, and heart failure pathogenesis. The project aims to provide insights into molecular mechanisms and identify potential therapeutic targets for heart failure.