Award
NIH Reporter #11384824
Mapping p53 dynamics to cell-fate outcomes in reprogramming and oncogenesis
Recipient
Duke University
Award Amount
$88,170.00
Ceiling
$88,170.00
Awarded
August 06, 2026
Identifier
11384824
Research project awarded to Duke University to study p53 protein dynamics in cell fate and cancer, involving synthetic gene circuits and 3D ovarian cancer models.
Description
The project focuses on understanding the role of the tumor suppressor protein p53 in cell fate transitions including cancer. The research involves designing synthetic gene circuits to track p53 levels during reprogramming. Extends investigations to 3D models of ovarian cancer to identify early drivers of tumor establishment.