Award
National Institute of Allergy and Infectious Diseases 1F31AI197467-01
Mechanisms of HBx Recognition and Epigenetic Regulation of HBV cccDNA
Recipient
WEILL MEDICAL COLL OF CORNELL UNIV, NEW YORK, NY, UNITED STATES
Award Amount
$50,114.00
Ceiling
$50,114.00
Awarded
March 30, 2026
Identifier
1F31AI197467-01
Research to understand how the HBx protein interacts with HBV cccDNA and host epigenetic factors to regulate viral transcription, aiming to find new therapeutic targets for chronic hepatitis B infection.
Description
This project aims to elucidate the mechanisms by which HBx recognizes and remodels HBV covalently closed circular DNA (cccDNA) and identify host epigenetic factors that regulate HBV transcription, providing insights into HBV pathogenesis and potential therapeutic targets for chronic HBV infection.