Award
NIH Reporter #1R01DK144506-01A1
Kidney tubule dysfunction in APOL1
Recipient
Veterans Medical Research Foundation / San Diego
Award Amount
$383,098.00
Ceiling
$383,098.00
Awarded
September 02, 2026
Identifier
1R01DK144506-01A1
Research project funded by NIDDK to study kidney tubule dysfunction related to APOL1 gene risk variants, focusing on biomarkers and kidney disease progression, particularly in African American populations.
Description
This project aims to investigate kidney tubule dysfunction among individuals with risk variants of the APOL1 gene, which increases the likelihood of kidney failure. The study will expand biomarker panels to assess kidney tubule health, analyze their role in kidney function decline, and evaluate tubular biomarkers in interstitial fibrosis and tubular atrophy. The research will utilize cohorts such as SPRINT, REGARDS, Nephrotic Syndrome Study Network, and Cure Glomerulopathy.