Award
National Institute of Mental Health 1F30MH143481-01
Investigating the Feasibility of Gene Therapy for the Treatment of TBRS
Recipient
Washington University, Saint Louis, MO
Award Amount
$36,673.00
Ceiling
$36,673.00
Awarded
February 16, 2026
Identifier
1F30MH143481-01
The award supports research on gene therapy for Tatton Brown Rahman Syndrome (TBRS) by restoring DNMT3A gene function using mouse models to evaluate potential treatment efficacy and improve outcomes for neurodevelopmental disorders.
Description
This project focuses on studying the potential for a treatment for Tatton Brown Rahman Syndrome (TBRS), a genetic disorder affecting brain development and causing learning disabilities, overgrowth, and other health issues. Using advanced genetics tools and mouse models, the study aims to test whether restoring the function of the gene DNMT3A can reverse the disorder's effects. The goal is to understand how gene therapy could help individuals with TBRS and similar developmental conditions, improving their health and quality of life.