Award
National Institute on Alcohol Abuse and Alcoholism 5R01AA030160-04
Epigenetic and metabolic mechanisms of environmentally-induced transgenerational germline dysfunction
Recipient
University of California Los Angeles
Award Amount
$344,429.00
Ceiling
$344,429.00
Awarded
May 05, 2026
Identifier
5R01AA030160-04
Research project investigating how in utero ethanol exposure causes transgenerational germline dysfunction through epigenetic and metabolic mechanisms, using C. elegans and epigenomic analyses.
Description
The overarching goal of this research is to dissect the genetic, epigenetic, and metabolic programs that encode and transmit a memory of environmental exposure across generations. The study focuses on how in utero ethanol exposure affects reproductive and neurological outcomes, with evidence suggesting transgenerational effects. The research combines the model system C. elegans with epigenomic analyses to understand the mechanisms of ethanol's transgenerational impact, hypothesizing that ethanol causes germline perturbations via alterations in histone acetylation.