Award
National Institute of Diabetes and Digestive and Kidney Diseases 5R01DK122558-05
Skeletal Effects of Type 1 Diabetes
Recipient
Creighton University
Award Amount
$341,725.00
Ceiling
$341,725.00
Awarded
August 15, 2024
Identifier
5R01DK122558-05
Research project funded to study bone tissue mechanical properties in type 1 diabetes patients to understand fracture risk and develop treatments.
Description
This project aims to investigate the mechanical properties of bone tissue in patients with insulin-dependent diabetes mellitus, focusing on chemical accumulation such as advanced glycation end-products (AGEs) and their impact on fracture risk. The study involves obtaining transilial bone biopsies from diabetic and matched non-diabetic subjects, performing mechanical testing, imaging, and tissue analysis. The ultimate goal is to develop treatment options to reduce fracture risk in diabetics, addressing a significant health concern.