Award
National Institute of Allergy and Infectious Diseases 5R01AI148541-05
Gut microbes modulate immune pathways in intestinal stem cells to influence their lineage
Recipient
Cornell University
Award Amount
$577,005.00
Ceiling
$577,005.00
Awarded
May 01, 2024
Identifier
5R01AI148541-05
Research project funded by NIAID to study how gut microbes modulate immune pathways in intestinal stem cells, influencing their lineage and potentially leading to new therapies for gut diseases.
Description
This project aims to elucidate the mechanisms by which gut microbes influence intestinal stem cell behavior and epithelial composition, with implications for understanding gut-related diseases and developing new therapies. It uses Drosophila melanogaster as a model to study how microbes affect intestinal stem cell proliferation and differentiation, focusing on immune signaling pathways.