Award
National Institute of Allergy and Infectious Diseases 5R01AI123383-10
Molecular Mechanisms for Carbohydrate Presentation to CD4+ T cells by MHCII Pathway
Recipient
Emory University
Award Amount
$465,058.00
Ceiling
$465,058.00
Awarded
July 29, 2026
Identifier
5R01AI123383-10
This award funds research to develop a knowledge-based glycoconjugate vaccine platform that enhances immune response to bacterial carbohydrate antigens by studying CD4+ T cell mechanisms, aiming to improve vaccine efficacy.
Description
The project aims to improve vaccine efficacy against bacterial diseases by understanding and harnessing T cell responses to carbohydrate antigens. The research involves establishing a new vaccine platform and characterizing immune responses to specific pneumococcal serotypes. It focuses on developing a new vaccine platform targeting carbohydrate antigens of bacteria, involving structural vaccine design and immune response characterization.