Award
National Heart, Lung, and Blood Institute 5R01HL153079-05
The Role of Airway Mucus in Infection and Inflammation
Recipient
University of Alabama at Birmingham
Award Amount
$445,370.00
Ceiling
$445,370.00
Awarded
May 15, 2025
Identifier
5R01HL153079-05
Research project funded by the National Heart Lung and Blood Institute to study the role of airway mucus in infection and inflammation in cystic fibrosis using animal models and advanced imaging techniques, aiming to improve understanding and treatment of chronic lung infections.
Description
This project investigates the mechanisms that cause patients with cystic fibrosis (CF) to transition acute infections into chronic ones, focusing on mucus abnormalities, inflammation, and the effect of CFTR modulators using a CF rat model. The study aims to understand early events leading to infection and progression in CF pulmonary disease and identify therapeutic targets.