Award
NIH Reporter #5R01AI146340-05
The Rv2623-Rv1747 interaction: regulation of the in vivo fate of M. tuberculosis
Recipient
Rutgers Biomedical and Health Sciences, Newark, NJ
Award Amount
$830,828.00
Ceiling
$830,828.00
Awarded
January 15, 2025
Identifier
5R01AI146340-05
Research project funded by NIAID to study the interaction of proteins Rv2623 and Rv1747 in Mycobacterium tuberculosis, focusing on bacterial growth regulation, latency, and reactivation mechanisms to inform tuberculosis treatment development.
Description
The project aims to understand how Rv2623, a protein of Mycobacterium tuberculosis, regulates bacterial growth and latency. It investigates the interaction between Rv2623 and Rv1747, their roles in cell wall biogenesis, and how they influence M. tuberculosis's ability to stay dormant or reactivate. The study employs biochemical, genetic, immunological, and computational approaches, including animal models, to elucidate the pathways involved in TB latency and reactivation.