Award
National Institute on Aging 5R01AG079133-05
Thinking about walking: Can digital phenotyping of mobility improve the prediction of Alzheimer's dementia and inform on the pathologies and proteins contributing to this association?
Recipient
Rush University Medical Center
Award Amount
$722,580.00
Ceiling
$722,580.00
Awarded
July 15, 2026
Identifier
5R01AG079133-05
A research project funded by the National Institute on Aging to improve prediction of Alzheimer's dementia using digital phenotyping of mobility and to explore underlying brain pathologies and proteins.
Description
This project aims to use digital mobility phenotyping, including sensors and cognitive metrics, to improve early prediction of Alzheimer’s dementia, identify brain pathologies and proteins involved, and understand the mechanisms linking mobility and dementia. The study will analyze data from the Rush Memory and Aging Project, incorporating multi-day wrist sensor data, brain proteome analysis, and brain pathology assessments to develop biomarkers and potential treatment targets.