Award
National Institute of Neurological Disorders and Stroke 5R01NS140419-02
Pathogenic Mechanisms of Inflammatory Subventricular Zone Injury in Preterm Infants
Recipient
Duke University
Award Amount
$630,892.00
Ceiling
$630,892.00
Awarded
February 05, 2026
Identifier
5R01NS140419-02
NIH awarded Duke University $630,892 to study inflammatory injury mechanisms in the subventricular zone of preterm infants, investigating immune signatures and therapeutic approaches targeting IL-1b.
Description
This NIH grant project aims to understand the immune mechanisms causing injury to the subventricular zone in preterm infants, focusing on monocyte infiltration, IL-1b production, and potential therapeutic targets to prevent neurodevelopmental impairment.