Award
National Cancer Institute 4R37CA242006-06
Defining the Role of Tumor-Neutral Crosstalk in head and Neck Cancer Progression and Treatment Resistance
Recipient
UNIVERSITY OF TX MD ANDERSON CAN CTR
Award Amount
$910,254.00
Ceiling
$910,254.00
Awarded
July 10, 2025
Identifier
4R37CA242006-06
This award funds research to understand how nerve interactions with tumors contribute to head and neck cancer progression and treatment resistance, aiming to identify new therapeutic targets.
Description
The project explores the mechanisms driving nerves to infiltrate tumors and support their growth and progression, focusing on tumor microenvironment interactions with nerve fibers arising from the peripheral nervous system. It aims to delineate signaling events between cancer cells and neurons, elucidate drivers of tumor-associated neuronal reprogramming, and characterize sensory nerve reprogramming in oral cancer progression.