Award
U.S. Department of Veterans Affairs 5I01BX006063-03
BCCMA: The Role of Sphingolipids in the Induction & Maintenance of Non-Small Cell Lung Cancer by Oncogenic KRAS
Recipient
VA VETERANS ADMINISTRATION HOSPITAL
Awarded
October 03, 2025
Identifier
5I01BX006063-03
The project explores cellular mechanisms involving oncogenic KRAS and sphingolipid metabolism to develop targeted therapeutics for non-small cell lung cancer, aiming to improve treatment outcomes for veterans.
Description
This project focuses on the role of sphingolipids, particularly ceramide kinase and ceramide-1-phosphate, in the development and maintenance of NSCLC driven by KRAS mutations. It aims to identify therapeutic targets and mechanisms to improve treatment outcomes for veterans with lung cancer.