Award
NIH Reporter #5R01NS128080-04
Mechanisms of migraine chronification and reversal
Recipient
Washington University, Saint Louis, MO, United States
Award Amount
$462,244.00
Ceiling
$462,244.00
Awarded
April 08, 2026
Identifier
5R01NS128080-04
Research grant investigating neuro-immune mechanisms in migraine chronification to identify therapeutic targets for reversing chronic migraine.
Description
This project aims to elucidate the role of neuro-immune interactions, particularly involving T cells and neuropeptides like CGRP and PACAP, in the development and resolution of migraine. The study will investigate how T cell subsets contribute to migraine chronification, the effects of ld-IL2 treatment on Treg cells, and the signaling pathways involved, with the goal of facilitating mechanism-based drug discovery.