Award
National Institute on Aging 1R21AG089974-01A1
The role of mitochondrial deficits in tauopathy-linked autophagy defects
Recipient
Rutgers, The State Univ of N.J.
Award Amount
$431,750.00
Ceiling
$431,750.00
Awarded
May 20, 2025
Identifier
1R21AG089974-01A1
Research project funded by the National Institute on Aging to study mitochondrial deficits in tauopathy and their impact on autophagy defects, aiming to explore Miro as a therapeutic target for Alzheimer's disease and related tauopathies.
Description
This project aims to provide mechanistic insights into mitochondrial roles in tau clearance and explore Miro as a potential therapeutic target for tauopathies. The study focuses on Alzheimer's disease and tauopathies, investigating the role of Mitochondrial Rho GTPase (Miro) in enhancing autophagy and reducing tau pathology.