Award
NIH Reporter #5F32HL170581-02
A Dynamic and Three-Dimensional Human Model of Hypoplastic Left Heart Syndrome to Probe Compromised Cardiomyocyte Proliferation
Recipient
Research Institute Nationwide Children's Hospital, Columbus, OH, United States
Award Amount
$80,224.00
Ceiling
$80,224.00
Awarded
August 26, 2025
Identifier
5F32HL170581-02
Research project to develop a 3D bioprinted human heart model to study Hypoplastic Left Heart Syndrome and understand cardiomyocyte proliferation defects.
Description
This project proposes using tissue engineering and iPSC technology to develop a 3D bioprinted heart model with disease-specific cells to study how biomechanical forces and stiffness affect cardiomyocyte proliferation, aiming to uncover new insights into HLHS pathogenesis.