Award
Eunice Kennedy Shriver National Institute of Child Health and Human Development 5R01HD103627-05
Dissect the mechanisms underlying interspecies pluripotent stem cell competition
Recipient
UT Southwestern Medical Center, Dallas, TX
Award Amount
$352,600.00
Ceiling
$352,600.00
Awarded
December 12, 2025
Identifier
5R01HD103627-05
The award supports research to understand and suppress interspecies pluripotent stem cell competition to improve interspecies organogenesis, addressing organ shortage through advanced stem cell and developmental biology techniques.
Description
This project aims to decipher the underlying molecular mechanisms and develop effective strategies to enable interspecies organogenesis by suppressing interspecies cell competition. It involves extensive molecular and cellular research, including transcriptome analysis and genetic manipulation, to address barriers to interspecies chimerism and organ generation.