Award
National Institute of Diabetes and Digestive and Kidney Diseases 5R01DK134647-04
The Role of Tcf7l2 in maintaining liver zonation and metabolic homeostasis
Recipient
Boston Children's Hospital, Boston, MA, United States
Award Amount
$497,561.00
Ceiling
$497,561.00
Awarded
January 16, 2026
Identifier
5R01DK134647-04
Research project funded by NIDDK to study the role of TCF7L2 in liver function and metabolism, focusing on diabetes and non-alcoholic fatty liver disease, using genomic and metabolomic methods.
Description
This project aims to determine TCF7L2's role in hepatic gene expression and metabolism, hypothesizing that TCF7L2 maintains liver zonation and homeostasis during fasting/feeding transitions and overnutrition. It involves advanced genomic and metabolomic techniques to understand diabetes and develop personalized strategies to prevent NAFLD and diabetic sequelae.